Ultrasound evaluation of patient-derived renal cell carcinoma xenografts in the chicken embryo model

Wednesday, May 25, 2016
Guest Presenters: Dr. Hon Leong and Matthew Lowerison, Western University

Topics Include:

  • Goal: Evaluate anti-angiogenic treatment effect on CAM RCC xenograft tumors to detect patient-specific drug resistance(s)
  • Presentation of both direct tumor core engraftments as well as work done on patient-derived cell-lines 
  • 3D power Doppler provides high quality estimates of tumor volume/vascularization and allows visualization feeding arterioles
  • Contrast-enhanced ultrasound permits quantification of tumor perfusion
  • Testing clinically relevant anti-angiogenic drugs: sunitinib, pazopanib, sorafenib, sirolimus, everolimus, and vehicle control (DMSO)
  • Ultrasound quantifications are combined to classify patient samples as either drug sensitive or drug resistant
  • Results validated with histology and clinical outcomes 



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Dr. Leong recieved his PhD in 2008 at the University of British Columbia through the Department of Pathology and Laboratory Medicine. This was research focused on platelet microparticles, autoantibodies, and transplant vasculopathy. He subsequently did a Post-doctoral Fellowship in the laboratories of Dr. Ann Chambers (2008-2014) and Dr. John Lewis (2008-2012). This was research focused on translational prostate and translational breast cancer research. He holds fellowships awarded by the Canadian Breast Cancer Foundation (update here) and DoD CDMRP Prostate Cancer Research Program.

Matthew Lowerison was born in Montreal, QC and raised in Winnipeg, MB. He received a DEC in Natural Science along with an International Baccalaureate Diploma (Sciences) at Vanier College in 2008. He received his BMSC at Western University in Honours Specialization in Medical Biophysics (Medical Sciences concentration) in 2011. His achievements were recognized with a Western Gold Medal for highest academic standing in his program. He then entered the department’s graduate program under the supervision of Drs. James C. Lacefield and Ann F. Chambers. He reclassified as a doctoral student in 2013 to pursue research focused on novel signal processing techniques on contrast-enhanced ultrasound images. A recent collaboration was founded with Drs. Hon Leong and Nicholas Power to extend this work to the chicken embryo chorioallantoic membrane xenograft model. This model allows for clinically translatable, patient-specific, drug efficacy testing to be performed rapidly and on a large scale.

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